Structural and biochemical characterization of Human PR70 in isolation and in complex with the scaffolding subunit of protein phosphatase 2A

• Main Authors: Dovega, Rebecca, Tsutakawa, Susan, Quistgaard, Esben M., Anandapadamanaban, Madhanagopal, Löw, Christian, Nordlund, Pär
• Other Authors: Soares, Claudio M.
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/104661; http://hdl.handle.net/10220/20290
• Institution: Nanyang Technological University

Protein Phosphatase 2A (PP2A) is a major Ser/Thr phosphatase involved in the regulation of various cellular processes. PP2A assembles into diverse trimeric holoenzymes, which consist of a scaffolding (A) subunit, a catalytic (C) subunit and various regulatory (B) subunits. Here we report a 2.0 Å cry...