Structural basis for PTPA interaction with the invariant C-terminal tail of PP2A

• Main Authors: Löw, Christian, Quistgaard, Esben M., Kovermann, Michael, Anandapadamanaban, Madhanagopal, Balbach, Jochen, Nordlund, Pär
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: https://hdl.handle.net/10356/106914; http://hdl.handle.net/10220/25197
• Institution: Nanyang Technological University

Protein phosphatase 2A (PP2A) is a highly abundant heterotrimeric Ser/Thr phosphatase involved in the regulation of a variety of signaling pathways. The PP2A phosphatase activator (PTPA) is an ATP-dependent activation chaperone, which plays a key role in the biogenesis of active PP2A. The C-terminal...