Orthogonally engineering matrix topography and rigidity to regulate multicellular morphology

• المؤلفون الرئيسيون: Hu, Benhui, Shi, Wenxiong, Wu, Yun-Long, Leow, Wan Ru, Cai, Pingqiang, Li, Shuzhou, Chen, Xiaodong
• مؤلفون آخرون: School of Materials Science & Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2014
• الموضوعات: DRNTU::Engineering::Materials
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/105186; http://hdl.handle.net/10220/20499
• المؤسسة: Nanyang Technological University

Programmable polymer substrates, which mimic the variable extracellular matrices in living systems, are used to regulate multicellular morphology, via orthogonally modulating the matrix topography and elasticity. The multicellular morphology is dependent on the competition between cell–matrix adhesion and cell–cell adhesion. Decreasing the cell–matrix adhesion provokes cytoskeleton reorganization, inhibits lamellipodial crawling, and thus enhances the leakiness of multicellular morphology.