The stem region of premembrane protein plays an important role in the virus surface protein rearrangement during dengue maturation

• Main Authors: Zhang, Q., Hunke, C., Seow, V., Lee, S., Tanner, L. B., Guan, X. L., Wenk, M. R., Fibriansah, G., Chew, P. L., Kukkaro, P., Shi, P.-Y., Lok, S.-M., Yau, Yin Hoe, Biuković, Goran, Shochat, Susana Geifman, Grüber, Gerhard
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Science::Biological sciences::Biochemistry
• Online Access: https://hdl.handle.net/10356/105326; http://hdl.handle.net/10220/17653
• Institution: Nanyang Technological University

Newly assembled dengue viruses (DENV) undergo maturation to become infectious particles. The maturation process involves major rearrangement of virus surface premembrane (prM) and envelope (E) proteins. The prM-E complexes on immature viruses are first assembled as trimeric spikes in the neutral pH...