Weak arene C - H⋅⋅⋅O hydrogen bonding in palladium-catalyzed arylation and vinylation of lactones

• Main Authors: Huang, Zhiyan, Chen, Zuliang, Lim, Li Hui, Quang, Gia Chuong Phan, Hirao, Hajime, Zhou, Jianrong Steve
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2013
• Online Access: https://hdl.handle.net/10356/105487; http://hdl.handle.net/10220/16585; http://dx.doi.org/10.1002/anie.201300481
• Institution: Nanyang Technological University

Weak force in action: In the title reaction, the palladium catalyst (see figure, left) uses weak CH⋅⋅⋅O hydrogen bonding to control the absolute configuration of the new stereocenter. A similar palladium catalyst (right) used conventional NH⋅⋅⋅O hydrogen bonding to guide stereoselection.