Comparative heterochromatin profiling reveals conserved and unique epigenome signatures linked to adaptation and development of malaria parasites

• Main Authors: Fraschka, Sabine A., Filarsky, Michael, Hoo, Regina, Niederwieser, Igor, Yam, Xue Yan, Mohring, Franziska, Huang, Ximei, Christensen, Peter R., Nosten, Francois, Bozdech, Zbynek, Russell, Bruce, Moon, Robert W., Marti, Matthias, Bártfai, Richárd, Voss, Till S., Brancucci, Nicolas M. B., Mushunje, Annals Tatenda, Preiser, Peter Rainer
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Plasmodium; Malaria; Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/106386; http://hdl.handle.net/10220/49617
• Institution: Nanyang Technological University

Heterochromatin-dependent gene silencing is central to the adaptation and survival of Plasmodium falciparum malaria parasites, allowing clonally variant gene expression during blood infection in humans. By assessing genome-wide heterochromatin protein 1 (HP1) occupancy, we present a comprehensive an...