Copper-catalyzed enantioselective conjugate addition of grignard reagents to methyl 4,4,4-trifluorocrotonate : synthesis of enantioenriched trifluoromethylated compounds

Copper-catalyzed enantioselective conjugate addition of grignard reagents to methyl 4,4,4-trifluorocrotonate : synthesis of enantioenriched trifluoromethylated compounds

Copper-catalyzed enantioselective 1,4-conjugate addition of methyl 4,4,4-trifluorocrotonate with aliphatic Grignard reagents to access an asymmetric tertiary carbon center attached with a trifluoromethyl group was achieved under mild reaction conditions. The desired products could be obtained in rea...

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Bibliographic Details
Main Authors: Zhang, Li-Ying, Zhou, Jia-Hui, Xu, Yun-He, Loh, Teck-Peng
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2015
Subjects:
DRNTU::Science::Chemistry::Organic chemistry::Carbanions
Online Access:https://hdl.handle.net/10356/106879
http://hdl.handle.net/10220/25142
http://dx.doi.org/10.1002/asia.201403303
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Institution: Nanyang Technological University
Language: English
Description
Summary:Copper-catalyzed enantioselective 1,4-conjugate addition of methyl 4,4,4-trifluorocrotonate with aliphatic Grignard reagents to access an asymmetric tertiary carbon center attached with a trifluoromethyl group was achieved under mild reaction conditions. The desired products could be obtained in reasonable yields and good enantioselectivities.

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