Copper-catalyzed enantioselective conjugate addition of grignard reagents to methyl 4,4,4-trifluorocrotonate : synthesis of enantioenriched trifluoromethylated compounds

Copper-catalyzed enantioselective conjugate addition of grignard reagents to methyl 4,4,4-trifluorocrotonate : synthesis of enantioenriched trifluoromethylated compounds

Copper-catalyzed enantioselective 1,4-conjugate addition of methyl 4,4,4-trifluorocrotonate with aliphatic Grignard reagents to access an asymmetric tertiary carbon center attached with a trifluoromethyl group was achieved under mild reaction conditions. The desired products could be obtained in rea...

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Main Authors: Zhang, Li-Ying, Zhou, Jia-Hui, Xu, Yun-He, Loh, Teck-Peng
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2015
Subjects:
DRNTU::Science::Chemistry::Organic chemistry::Carbanions
Online Access:https://hdl.handle.net/10356/106879
http://hdl.handle.net/10220/25142
http://dx.doi.org/10.1002/asia.201403303
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1068792019-12-06T22:20:12Z Copper-catalyzed enantioselective conjugate addition of grignard reagents to methyl 4,4,4-trifluorocrotonate : synthesis of enantioenriched trifluoromethylated compounds Zhang, Li-Ying Zhou, Jia-Hui Xu, Yun-He Loh, Teck-Peng School of Physical and Mathematical Sciences DRNTU::Science::Chemistry::Organic chemistry::Carbanions Copper-catalyzed enantioselective 1,4-conjugate addition of methyl 4,4,4-trifluorocrotonate with aliphatic Grignard reagents to access an asymmetric tertiary carbon center attached with a trifluoromethyl group was achieved under mild reaction conditions. The desired products could be obtained in reasonable yields and good enantioselectivities. 2015-03-02T06:56:38Z 2019-12-06T22:20:12Z 2015-03-02T06:56:38Z 2019-12-06T22:20:12Z 2015 2015 Journal Article Zhang, L.-Y., Zhou, J.-H., Xu, Y.-H., & Loh, T.-P. (2015). Copper-catalyzed enantioselective conjugate addition of grignard reagents to methyl 4,4,4-trifluorocrotonate : synthesis of enantioenriched trifluoromethylated compounds. Chemistry - an Asian journal, 10(4), 844-848. 1861-4728 https://hdl.handle.net/10356/106879 http://hdl.handle.net/10220/25142 http://dx.doi.org/10.1002/asia.201403303 en Chemistry - an Asian journal © 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic DRNTU::Science::Chemistry::Organic chemistry::Carbanions
spellingShingle DRNTU::Science::Chemistry::Organic chemistry::Carbanions
Zhang, Li-Ying
Zhou, Jia-Hui
Xu, Yun-He
Loh, Teck-Peng
Copper-catalyzed enantioselective conjugate addition of grignard reagents to methyl 4,4,4-trifluorocrotonate : synthesis of enantioenriched trifluoromethylated compounds
description Copper-catalyzed enantioselective 1,4-conjugate addition of methyl 4,4,4-trifluorocrotonate with aliphatic Grignard reagents to access an asymmetric tertiary carbon center attached with a trifluoromethyl group was achieved under mild reaction conditions. The desired products could be obtained in reasonable yields and good enantioselectivities.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Zhang, Li-Ying
Zhou, Jia-Hui
Xu, Yun-He
Loh, Teck-Peng
format Article
author Zhang, Li-Ying
Zhou, Jia-Hui
Xu, Yun-He
Loh, Teck-Peng
author_sort Zhang, Li-Ying
title Copper-catalyzed enantioselective conjugate addition of grignard reagents to methyl 4,4,4-trifluorocrotonate : synthesis of enantioenriched trifluoromethylated compounds
title_short Copper-catalyzed enantioselective conjugate addition of grignard reagents to methyl 4,4,4-trifluorocrotonate : synthesis of enantioenriched trifluoromethylated compounds
title_full Copper-catalyzed enantioselective conjugate addition of grignard reagents to methyl 4,4,4-trifluorocrotonate : synthesis of enantioenriched trifluoromethylated compounds
title_fullStr Copper-catalyzed enantioselective conjugate addition of grignard reagents to methyl 4,4,4-trifluorocrotonate : synthesis of enantioenriched trifluoromethylated compounds
title_full_unstemmed Copper-catalyzed enantioselective conjugate addition of grignard reagents to methyl 4,4,4-trifluorocrotonate : synthesis of enantioenriched trifluoromethylated compounds
title_sort copper-catalyzed enantioselective conjugate addition of grignard reagents to methyl 4,4,4-trifluorocrotonate : synthesis of enantioenriched trifluoromethylated compounds
publishDate 2015
url https://hdl.handle.net/10356/106879
http://hdl.handle.net/10220/25142
http://dx.doi.org/10.1002/asia.201403303
_version_ 1681044433322115072

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