Copper-catalyzed enantioselective conjugate addition of grignard reagents to methyl 4,4,4-trifluorocrotonate : synthesis of enantioenriched trifluoromethylated compounds

• Main Authors: Zhang, Li-Ying, Zhou, Jia-Hui, Xu, Yun-He, Loh, Teck-Peng
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Chemistry::Organic chemistry::Carbanions
• Online Access: https://hdl.handle.net/10356/106879; http://hdl.handle.net/10220/25142; http://dx.doi.org/10.1002/asia.201403303
• Institution: Nanyang Technological University

Copper-catalyzed enantioselective 1,4-conjugate addition of methyl 4,4,4-trifluorocrotonate with aliphatic Grignard reagents to access an asymmetric tertiary carbon center attached with a trifluoromethyl group was achieved under mild reaction conditions. The desired products could be obtained in rea...