Insights into the programmed ketoreduction of partially reducing polyketide synthases : stereo- and substrate-specificity of the ketoreductase domain

• Main Authors: Soehano, Ishin, Yang, Lifeng, Ding, Feiqing, Sun, Huihua, Low, Zhen Jie, Liu, Xuewei, Liang, Zhao-Xun
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: https://hdl.handle.net/10356/106999; http://hdl.handle.net/10220/25227
• Institution: Nanyang Technological University

One of the hallmarks of iterative polyketide synthases (PKSs) is the programming mechanism which is essential for the generation of structurally diverse polyketide products. In partially reducing iterative PKSs (PR-PKSs), the programming mechanism is mainly dictated by the ketoreductase (KR) domain....