Insights into the programmed ketoreduction of partially reducing polyketide synthases : stereo- and substrate-specificity of the ketoreductase domain

• المؤلفون الرئيسيون: Soehano, Ishin, Yang, Lifeng, Ding, Feiqing, Sun, Huihua, Low, Zhen Jie, Liu, Xuewei, Liang, Zhao-Xun
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2015
• الموضوعات: DRNTU::Science::Biological sciences::Molecular biology
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/106999; http://hdl.handle.net/10220/25227
• المؤسسة: Nanyang Technological University

One of the hallmarks of iterative polyketide synthases (PKSs) is the programming mechanism which is essential for the generation of structurally diverse polyketide products. In partially reducing iterative PKSs (PR-PKSs), the programming mechanism is mainly dictated by the ketoreductase (KR) domain....