Macrolide synthesis through intramolecular oxidative cross‐coupling of alkenes
A RhIII‐catalyzed intramolecular oxidative cross‐coupling between double bonds for the synthesis of macrolides is described. Under the optimized reaction conditions, macrocycles containing a diene moiety can be formed in reasonable yields and with excellent chemo‐ and stereoselectivity. This method...
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sg-ntu-dr.10356-1377232020-04-13T01:24:17Z Macrolide synthesis through intramolecular oxidative cross‐coupling of alkenes Jiang, Bing Zhao, Meng Li, Shu-Sen Xu, Yun-He Loh, Teck-Peng School of Physical and Mathematical Sciences Science::Chemistry C-H Activation Cross-coupling A RhIII‐catalyzed intramolecular oxidative cross‐coupling between double bonds for the synthesis of macrolides is described. Under the optimized reaction conditions, macrocycles containing a diene moiety can be formed in reasonable yields and with excellent chemo‐ and stereoselectivity. This method provides an efficient approach to synthesize macrocyclic compounds containing a 1,3‐conjugated diene structure. 2020-04-13T01:24:16Z 2020-04-13T01:24:16Z 2018 Journal Article Jiang, B., Zhao, M., Li, S.-S., Xu, Y.-H., & Loh, T.-P. (2018). Macrolide synthesis through intramolecular oxidative cross‐coupling of alkenes. Angewandte Chemie International Edition, 57(2), 555-559. doi:10.1002/anie.201710601 1433-7851 https://hdl.handle.net/10356/137723 10.1002/anie.201710601 29193496 2-s2.0-85042094348 2 57 555 559 en Angewandte Chemie International Edition © 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. All rights reserved. |
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English |
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Science::Chemistry C-H Activation Cross-coupling |
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Science::Chemistry C-H Activation Cross-coupling Jiang, Bing Zhao, Meng Li, Shu-Sen Xu, Yun-He Loh, Teck-Peng Macrolide synthesis through intramolecular oxidative cross‐coupling of alkenes |
| description |
A RhIII‐catalyzed intramolecular oxidative cross‐coupling between double bonds for the synthesis of macrolides is described. Under the optimized reaction conditions, macrocycles containing a diene moiety can be formed in reasonable yields and with excellent chemo‐ and stereoselectivity. This method provides an efficient approach to synthesize macrocyclic compounds containing a 1,3‐conjugated diene structure. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Jiang, Bing Zhao, Meng Li, Shu-Sen Xu, Yun-He Loh, Teck-Peng |
| format |
Article |
| author |
Jiang, Bing Zhao, Meng Li, Shu-Sen Xu, Yun-He Loh, Teck-Peng |
| author_sort |
Jiang, Bing |
| title |
Macrolide synthesis through intramolecular oxidative cross‐coupling of alkenes |
| title_short |
Macrolide synthesis through intramolecular oxidative cross‐coupling of alkenes |
| title_full |
Macrolide synthesis through intramolecular oxidative cross‐coupling of alkenes |
| title_fullStr |
Macrolide synthesis through intramolecular oxidative cross‐coupling of alkenes |
| title_full_unstemmed |
Macrolide synthesis through intramolecular oxidative cross‐coupling of alkenes |
| title_sort |
macrolide synthesis through intramolecular oxidative cross‐coupling of alkenes |
| publishDate |
2020 |
| url |
https://hdl.handle.net/10356/137723 |
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1681058861292716032 |