Macrolide synthesis through intramolecular oxidative cross‐coupling of alkenes

• Main Authors: Jiang, Bing, Zhao, Meng, Li, Shu-Sen, Xu, Yun-He, Loh, Teck-Peng
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry; C-H Activation; Cross-coupling
• Online Access: https://hdl.handle.net/10356/137723
• Institution: Nanyang Technological University

A RhIII‐catalyzed intramolecular oxidative cross‐coupling between double bonds for the synthesis of macrolides is described. Under the optimized reaction conditions, macrocycles containing a diene moiety can be formed in reasonable yields and with excellent chemo‐ and stereoselectivity. This method...