NHC-catalyzed chemoselective reactions of enals and aminobenzaldehydes for access to chiral dihydroquinolines

• Main Authors: Wu, Shuquan, Liu, Changyi, Luo, Guoyong, Jin, Zhichao, Zheng, Pengcheng, Chi, Robin Yonggui
• 其他作者: School of Physical and Mathematical Sciences
• 格式: Article
• 語言: English
• 出版: 2020
• 主題: Science::Chemistry::Organic chemistry; Chemoselectivity; Dihydroquinolines
• 在線閱讀: https://hdl.handle.net/10356/137827
• 機構: Nanyang Technological University

An N-heterocyclic carbene (NHC)-catalyzed reaction between α-bromoenals and 2-aminoaldehydes has been developed. Key steps include chemoselective reaction of the NHC catalyst with one of the aldehyde substrates (the bromoenal) to eventually generate an α,β-unsaturated acylazolium intermediate. Addit...