A sustained antiviral host response in respiratory syncytial virus infected human nasal epithelium does not prevent progeny virus production

Respiratory syncytial virus infection was examined using a human nasal epithelial cell model. Maximum levels of shed-virus were produced at between 3 and 5 days post-infection (dpi), and the infectivity of the shed-virus was stable up to 10 dpi. The highest levels of interferon signalling were recor...

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Main Authors: Huong, Tra Nguyen, Yan, Yan, Muhammad Raihan Jumat, Lui, Jing, Tan, Boon Huan, Wang, De Yun, Sugrue, Richard J.
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2020
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Online Access:https://hdl.handle.net/10356/138849
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1388492020-05-13T06:11:49Z A sustained antiviral host response in respiratory syncytial virus infected human nasal epithelium does not prevent progeny virus production Huong, Tra Nguyen Yan, Yan Muhammad Raihan Jumat Lui, Jing Tan, Boon Huan Wang, De Yun Sugrue, Richard J. School of Biological Sciences Engineering::Electrical and electronic engineering Respiratory Syncytial Virus Nasal Epithelium Respiratory syncytial virus infection was examined using a human nasal epithelial cell model. Maximum levels of shed-virus were produced at between 3 and 5 days post-infection (dpi), and the infectivity of the shed-virus was stable up to 10 dpi. The highest levels of interferon signalling were recorded at 2dpi, and infection induced a widespread antivirus response in the nasal epithelium, involving both infected cells and non-infected cells. Although these cellular responses were associated with reduced levels of progeny virus production and restricted virus spread, they did not inhibit the infectivity virus that is shed early in infection. In the clinical context these data suggest that although the host cell response in the nasal epithelium may restrict the levels of progeny virus particles produced, the stability of the shed-virus in the nasal mucosa may be an important factor in both disease progression and virus transmission. MOE (Min. of Education, S’pore) NMRC (Natl Medical Research Council, S’pore) 2020-05-13T06:11:49Z 2020-05-13T06:11:49Z 2018 Journal Article Huong, T. N., Yan, Y., Muhammad Raihan Jumat., Lui, J., Tan, B. H., Wang, D. Y., & Sugrue, R. J. (2018). A sustained antiviral host response in respiratory syncytial virus infected human nasal epithelium does not prevent progeny virus production. Virology, 521, 20-32. doi:10.1016/j.virol.2018.05.012 1096-0341 https://hdl.handle.net/10356/138849 10.1016/j.virol.2018.05.012 29870884 2-s2.0-85047813448 521 20 32 en Virology © 2018 Elsevier Inc. All rights reserved.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Engineering::Electrical and electronic engineering
Respiratory Syncytial Virus
Nasal Epithelium
spellingShingle Engineering::Electrical and electronic engineering
Respiratory Syncytial Virus
Nasal Epithelium
Huong, Tra Nguyen
Yan, Yan
Muhammad Raihan Jumat
Lui, Jing
Tan, Boon Huan
Wang, De Yun
Sugrue, Richard J.
A sustained antiviral host response in respiratory syncytial virus infected human nasal epithelium does not prevent progeny virus production
description Respiratory syncytial virus infection was examined using a human nasal epithelial cell model. Maximum levels of shed-virus were produced at between 3 and 5 days post-infection (dpi), and the infectivity of the shed-virus was stable up to 10 dpi. The highest levels of interferon signalling were recorded at 2dpi, and infection induced a widespread antivirus response in the nasal epithelium, involving both infected cells and non-infected cells. Although these cellular responses were associated with reduced levels of progeny virus production and restricted virus spread, they did not inhibit the infectivity virus that is shed early in infection. In the clinical context these data suggest that although the host cell response in the nasal epithelium may restrict the levels of progeny virus particles produced, the stability of the shed-virus in the nasal mucosa may be an important factor in both disease progression and virus transmission.
author2 School of Biological Sciences
author_facet School of Biological Sciences
Huong, Tra Nguyen
Yan, Yan
Muhammad Raihan Jumat
Lui, Jing
Tan, Boon Huan
Wang, De Yun
Sugrue, Richard J.
format Article
author Huong, Tra Nguyen
Yan, Yan
Muhammad Raihan Jumat
Lui, Jing
Tan, Boon Huan
Wang, De Yun
Sugrue, Richard J.
author_sort Huong, Tra Nguyen
title A sustained antiviral host response in respiratory syncytial virus infected human nasal epithelium does not prevent progeny virus production
title_short A sustained antiviral host response in respiratory syncytial virus infected human nasal epithelium does not prevent progeny virus production
title_full A sustained antiviral host response in respiratory syncytial virus infected human nasal epithelium does not prevent progeny virus production
title_fullStr A sustained antiviral host response in respiratory syncytial virus infected human nasal epithelium does not prevent progeny virus production
title_full_unstemmed A sustained antiviral host response in respiratory syncytial virus infected human nasal epithelium does not prevent progeny virus production
title_sort sustained antiviral host response in respiratory syncytial virus infected human nasal epithelium does not prevent progeny virus production
publishDate 2020
url https://hdl.handle.net/10356/138849
_version_ 1681058348392251392