A sustained antiviral host response in respiratory syncytial virus infected human nasal epithelium does not prevent progeny virus production

• Main Authors: Huong, Tra Nguyen, Yan, Yan, Muhammad Raihan Jumat, Lui, Jing, Tan, Boon Huan, Wang, De Yun, Sugrue, Richard J.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Electrical and electronic engineering; Respiratory Syncytial Virus; Nasal Epithelium
• Online Access: https://hdl.handle.net/10356/138849
• Institution: Nanyang Technological University

Respiratory syncytial virus infection was examined using a human nasal epithelial cell model. Maximum levels of shed-virus were produced at between 3 and 5 days post-infection (dpi), and the infectivity of the shed-virus was stable up to 10 dpi. The highest levels of interferon signalling were recor...