Targeted therapy for the post-operative conjunctiva : SPARC silencing reduces collagen deposition

• المؤلفون الرئيسيون: Seet, Li Fong, Tan, Yang Fei, Toh, Li Zhen, Chu, Stephanie Wai Ling, Lee, Ying Shi, Venkatraman, Subbu Subramanian, Wong, Tina Tzee Ling
• مؤلفون آخرون: School of Materials Science & Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2020
• الموضوعات: Engineering::Materials; Science::Medicine; Conjunctiva; Experimental-animal Models
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/138940
• المؤسسة: Nanyang Technological University

Background: To develop targeted antifibrotic therapy for glaucoma filtration surgery; this study determines the effectiveness of small interfering RNA (siRNA) to reduce in vivo secreted protein acidic and rich in cysteine (SPARC) expression using the mouse model of conjunctival scarring. Methods: Ex...