Targeted therapy for the post-operative conjunctiva : SPARC silencing reduces collagen deposition

• Main Authors: Seet, Li Fong, Tan, Yang Fei, Toh, Li Zhen, Chu, Stephanie Wai Ling, Lee, Ying Shi, Venkatraman, Subbu Subramanian, Wong, Tina Tzee Ling
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Materials; Science::Medicine; Conjunctiva; Experimental-animal Models
• Online Access: https://hdl.handle.net/10356/138940
• Institution: Nanyang Technological University

Background: To develop targeted antifibrotic therapy for glaucoma filtration surgery; this study determines the effectiveness of small interfering RNA (siRNA) to reduce in vivo secreted protein acidic and rich in cysteine (SPARC) expression using the mouse model of conjunctival scarring. Methods: Ex...