Sungeidines from a non-canonical enediyne biosynthetic pathway

• Main Authors: Low, Zhen Jie, Ma, Guang-Lei, Tran, Hoa Thi, Zou, Yike, Xiong, Juan, Pang, Limei, Nuryyeva, Selbi, Ye, Hong, Hu, Jin-Feng, Houk, K. N., Liang, Zhao-Xun
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences::Microbiology; Science::Biological sciences::Biochemistry; Natural Product; Biosynthesis
• Online Access: https://hdl.handle.net/10356/138953
• Institution: Nanyang Technological University

We report the genome-guided discovery of sungeidines, a class of microbial secondary metabolites with unique structural features. Despite evolutionary relationships with dynemicin-type enediynes, the sungeidines are produced by a biosynthetic gene cluster (BGC) that exhibits distinct differences fro...