Overexpression, purification, enzymatic and microscopic characterization of recombinant mycobacterial F-ATP synthase

• Main Authors: Saw, Wuan-Geok, Wong, Chui-Fann, Dick, Thomas, Grüber, Gerhard
• 其他作者: School of Biological Sciences
• 格式: Article
• 語言: English
• 出版: 2020
• 主題: Science::Biological sciences::Biochemistry; Science::Biological sciences::Molecular biology; F-ATP Synthase; Bioenergetics
• 在線閱讀: https://hdl.handle.net/10356/139317
• 機構: Nanyang Technological University

The F-ATP synthase is an essential enzyme in mycobacteria, including the pathogenic Mycobacterium tuberculosis. Several new compounds in the TB-drug pipeline target the F-ATP synthase. In light of the importance and pharmacological attractiveness of this novel antibiotic target, tools have to be dev...