Pyrroline synthesis via visible‐light‐promoted hydroimination of unactivated alkenes with N,N′‐dimethylpropylene urea as H‐donor

Pyrroline synthesis via visible‐light‐promoted hydroimination of unactivated alkenes with N,N′‐dimethylpropylene urea as H‐donor

Synthesis of 3,4-pyrroline derivatives via visible-light-induced hydro/oxyimination of unactivated olefins is reported. In the presence of the photoredox catalyst fac-Ir(ppy)3, the key iminyl radical intermediate can be readily generated from O-acyl oximes, and undergoes intramolecular cyclization a...

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Bibliographic Details
Main Authors: Cai, Sai-Hu, Wang, Ding-Xing, Ye, Lu, Liu, Ze-Yao, Feng, Chao, Loh, Teck-Peng
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2020
Subjects:
Science::Chemistry
N-heterocycles
Visible Light
Online Access:https://hdl.handle.net/10356/139419
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Institution: Nanyang Technological University
Language: English
Description
Summary:Synthesis of 3,4-pyrroline derivatives via visible-light-induced hydro/oxyimination of unactivated olefins is reported. In the presence of the photoredox catalyst fac-Ir(ppy)3, the key iminyl radical intermediate can be readily generated from O-acyl oximes, and undergoes intramolecular cyclization and H-abstraction from solvent or is trapped by TEMPO to give the corresponding hydro/oxyimination product, respectively. Mechanistic investigations indicate that N,N′-dimethylpropylene urea (DMPU) works as both reducing agent for catalyst regeneration and H-donor for product formation in this process.

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