Single molecule manipulation of nucleic acid structures using optical tweezers

Single molecule manipulation of nucleic acid structures using optical tweezers

Optical tweezers are versatile and precise tools that are well suited for single molecule studies. Here, optical tweezers is used to study the mechanical unfolding of five RNA structures. The studying of mechanical unfolding is crucial to understand the many cellular processes that involves RNA, lik...

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Bibliographic Details
Main Author: Tan, Kwan Ann
Other Authors: Chen Gang
Format: Final Year Project
Language:English
Published: Nanyang Technological University 2020
Subjects:
Science::Biological sciences::Biophysics
Science::Physics
Online Access:https://hdl.handle.net/10356/140002
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Institution: Nanyang Technological University
Language: English
Description
Summary:Optical tweezers are versatile and precise tools that are well suited for single molecule studies. Here, optical tweezers is used to study the mechanical unfolding of five RNA structures. The studying of mechanical unfolding is crucial to understand the many cellular processes that involves RNA, like translation. We find that hairpin-like structures can unfold reversibly at pH 7.3.

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