Single molecule manipulation of nucleic acid structures using optical tweezers

Single molecule manipulation of nucleic acid structures using optical tweezers

Optical tweezers are versatile and precise tools that are well suited for single molecule studies. Here, optical tweezers is used to study the mechanical unfolding of five RNA structures. The studying of mechanical unfolding is crucial to understand the many cellular processes that involves RNA, lik...

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Main Author: Tan, Kwan Ann
Other Authors: Chen Gang
Format: Final Year Project
Language:English
Published: Nanyang Technological University 2020
Subjects:
Science::Biological sciences::Biophysics
Science::Physics
Online Access:https://hdl.handle.net/10356/140002
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1400022023-02-28T23:11:59Z Single molecule manipulation of nucleic acid structures using optical tweezers Tan, Kwan Ann Chen Gang School of Physical and Mathematical Sciences rnachen@ntu.edu.sg Science::Biological sciences::Biophysics Science::Physics Optical tweezers are versatile and precise tools that are well suited for single molecule studies. Here, optical tweezers is used to study the mechanical unfolding of five RNA structures. The studying of mechanical unfolding is crucial to understand the many cellular processes that involves RNA, like translation. We find that hairpin-like structures can unfold reversibly at pH 7.3. Bachelor of Science in Physics 2020-05-26T03:35:59Z 2020-05-26T03:35:59Z 2020 Final Year Project (FYP) https://hdl.handle.net/10356/140002 en application/pdf Nanyang Technological University
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Biological sciences::Biophysics
Science::Physics
spellingShingle Science::Biological sciences::Biophysics
Science::Physics
Tan, Kwan Ann
Single molecule manipulation of nucleic acid structures using optical tweezers
description Optical tweezers are versatile and precise tools that are well suited for single molecule studies. Here, optical tweezers is used to study the mechanical unfolding of five RNA structures. The studying of mechanical unfolding is crucial to understand the many cellular processes that involves RNA, like translation. We find that hairpin-like structures can unfold reversibly at pH 7.3.
author2 Chen Gang
author_facet Chen Gang
Tan, Kwan Ann
format Final Year Project
author Tan, Kwan Ann
author_sort Tan, Kwan Ann
title Single molecule manipulation of nucleic acid structures using optical tweezers
title_short Single molecule manipulation of nucleic acid structures using optical tweezers
title_full Single molecule manipulation of nucleic acid structures using optical tweezers
title_fullStr Single molecule manipulation of nucleic acid structures using optical tweezers
title_full_unstemmed Single molecule manipulation of nucleic acid structures using optical tweezers
title_sort single molecule manipulation of nucleic acid structures using optical tweezers
publisher Nanyang Technological University
publishDate 2020
url https://hdl.handle.net/10356/140002
_version_ 1759853589620064256

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