A minimal sequence for left‐handed G‐quadruplex formation

• Main Authors: Bakalar, Blaž, Heddi, Brahim, Schmitt, Emmanuelle, Mechulam, Yves, Phan, Anh Tuân
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Chemistry; Circular Dichroism; DNA
• Online Access: https://hdl.handle.net/10356/140140
• Institution: Nanyang Technological University

Recently, we observed the first example of a left‐handed G‐quadruplex structure formed by natural DNA, named Z‐G4 . We analysed the Z‐G4 structure and inspected its primary 28‐nt sequence in order to identify motifs that convey the unique left‐handed twist. Using circular dichroism spectroscopy, NMR...