Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes

• Main Authors: Limwongyut, Jakarin, Liu, Yang, Chilambi, Gayatri Shankar, Seviour, Thomas, Hinks, Jamie, Mu, Yuguang, Bazan, Guillermo C.
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Bioengineering; Conjugated Oligoelectrolyte; Biological Membranes
• Online Access: https://hdl.handle.net/10356/140615
• Institution: Nanyang Technological University

A three-dimensional conjugated oligoelectrolyte (COE) bearing a [2.2]paracyclophane unit (COE2-3-pCp) was synthesized. Its biological activity was determined both in vivo and in silicon within the context of membrane perturbation and biocompatibility. Molecular dynamics simulations indicate that, co...