Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes

Interactions of a paracyclophane-based conjugated oligoelectrolyte with biological membranes

A three-dimensional conjugated oligoelectrolyte (COE) bearing a [2.2]paracyclophane unit (COE2-3-pCp) was synthesized. Its biological activity was determined both in vivo and in silicon within the context of membrane perturbation and biocompatibility. Molecular dynamics simulations indicate that, co...

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Bibliographic Details
Main Authors: Limwongyut, Jakarin, Liu, Yang, Chilambi, Gayatri Shankar, Seviour, Thomas, Hinks, Jamie, Mu, Yuguang, Bazan, Guillermo C.
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2020
Subjects:
Engineering::Bioengineering
Conjugated Oligoelectrolyte
Biological Membranes
Online Access:https://hdl.handle.net/10356/140615
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Institution: Nanyang Technological University
Language: English
Description
Summary:A three-dimensional conjugated oligoelectrolyte (COE) bearing a [2.2]paracyclophane unit (COE2-3-pCp) was synthesized. Its biological activity was determined both in vivo and in silicon within the context of membrane perturbation and biocompatibility. Molecular dynamics simulations indicate that, compared to its linear analog (COE2-3C), COE2-3-pCp introduces more lipid disorder with higher extent of membrane thinning. COE2-3-pCp also exhibits a higher MIC towards E. coli K12 and yeast, while maintaining similar levels of membrane permeabilization. These findings suggest a new design of COEs as biocompatible cell permeabilizers.

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