Ternary nanoparticle complex of ciprofloxacin exhibiting sustained release at gastric pH prepared by co-complexation with polyanions and an ionic amphiphile

• Main Authors: Dong, Bingxue, Cheow, Wean Sin, Hadinoto, Kunn
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Ternary nanoparticle complex of ciprofloxacin exhibiting sustained release at gastric pH prepared by co-complexation with polyanions and an ionic amphiphile; Engineering::Chemical engineering; Nanoparticle Complex; Sustained Drug Release
• Online Access: https://hdl.handle.net/10356/141829
• Institution: Nanyang Technological University

Poor bioavailability of the broad spectrum antibiotic ciprofloxacin (CIP) is caused by its narrow absorption window in the stomach. With the aim of prolonging the gastric residence time of CIP, we prepared a ternary nanoparticle complex (nanoplex) of CIP by co-complexation with polyanions (sodium de...