In vivo visualization of β-cells by targeting of GPR44

• Main Authors: Eriksson, Olof, Johnström, Peter, Cselenyi, Zsolt, Jahan, Mahabuba, Selvaraju, Ram K., Jensen-Waern, Marianne, Takano, Akihiro, Winzell, Maria Sörhede, Halldin, Christer, Skrtic, Stanko, Korsgren, Olle
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2020
• 主題: Science::Medicine; In Vivo; GPR44
• 在線閱讀: https://hdl.handle.net/10356/142005
• 機構: Nanyang Technological University

GPR44 expression has recently been described as highly β-cell selective in the human pancreas and constitutes a tentative surrogate imaging biomarker in diabetes. A radiolabeled small-molecule GPR44 antagonist, [11C]AZ12204657, was evaluated for visualization of β-cells in pigs and nonhuman primates...