Fatty acid metabolism driven mitochondrial bioenergetics promotes advanced developmental phenotypes in human induced pluripotent stem cell derived cardiomyocytes

• Main Authors: Ramachandra, Chrishan J. A., Mehta, Ashish, Wong, Philip, Ja, K. P. Myu Mai, Fritsche-Danielson, Regina, Bhat, Ratan V., Hausenloy, Derek J., Kovalik, Jean-Paul, Shim, Winston
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Materials; Mitochondria; Metabolism
• Online Access: https://hdl.handle.net/10356/142041
• Institution: Nanyang Technological University

Background: Preferential utilization of fatty acids for ATP production represents an advanced metabolic phenotype in developing cardiomyocytes. We investigated whether this phenotype could be attained in human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) and assessed its influenc...