Complement activation in vitro and reactogenicity of low-molecular weight dextran-coated SPIONs in the pig CARPA model : correlation with physicochemical features and clinical information

• Main Authors: Fülöp, Tamás, Nemes, Réka, Mészáros, Tamás, Urbanics, Rudolf, Kok, Robbert Jan, Jackman, Joshua A., Cho, Nam-Joon, Storm, Gert, Szebeni, János
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2020
• Subjects: Engineering::Materials; Complement; Hypersensitivity Reactions
• Online Access: https://hdl.handle.net/10356/142114
• Institution: Nanyang Technological University

The unique magnetic properties of superparamagnetic iron oxide nanoparticles (SPIONs) have led to their increasing use in drug delivery and imaging applications. Some polymer-coated SPIONs, however, share with many other nanoparticles the potential of causing hypersensitivity reactions (HSRs) known...