NS5 from dengue virus serotype 2 can adopt a conformation analogous to that of its Zika virus and Japanese encephalitis virus homologues

• Main Authors: El Sahili, Abbas, Soh, Sherryl Tingjin, Schiltz, Jonas, Gharbi-Ayachi, Aïcha, Seh, Cheah Chen, Shi, Pei-Yong, Lim, Siew Pheng, Lescar, Julien
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences; Flaviviruses; Dengue Virus
• Online Access: https://hdl.handle.net/10356/142215
• Institution: Nanyang Technological University

Flavivirus nonstructural protein 5 (NS5) contains an N-terminal methyltransferase (MTase) domain and a C-terminal polymerase (RNA-dependent RNA polymerase [RdRp]) domain fused through a 9-amino-acid linker. While the individual NS5 domains are structurally conserved, in the full-length protein, thei...