Synthesis of stereoprojecting, chiral N-C(sp3)-E type pincer complexes

Synthesis of stereoprojecting, chiral N-C(sp3)-E type pincer complexes

A synthetic strategy to generate chiral N-C(sp3)-E (E = S, O) pincer complexes incorporating enhanced stereoprojecting groups at the N-arm site has been established. The synthesis of the tridentate pincer ligand was carried out via palladacycle-catalyzed asymmetric hydrophosphination of N-chelating...

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Bibliographic Details
Main Authors: Balázs, László B., Tay, Wee Shan, Li, Yongxin, Pullarkat, Sumod Appukuttan, Leung, Pak-Hing
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2020
Subjects:
Science::Chemistry
Palladium
Modification
Online Access:https://hdl.handle.net/10356/142536
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Institution: Nanyang Technological University
Language: English
Description
Summary:A synthetic strategy to generate chiral N-C(sp3)-E (E = S, O) pincer complexes incorporating enhanced stereoprojecting groups at the N-arm site has been established. The synthesis of the tridentate pincer ligand was carried out via palladacycle-catalyzed asymmetric hydrophosphination of N-chelating enones. The chelation properties of the substrates were initially demonstrated on C(sp2)-N type palladacycles. The extended substrate scope allows versatile structural modifications on the ligand backbone. Subsequent cyclometalation provided N-C(sp3)-E complexes in a diastereoselective reaction.

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