Synthesis of stereoprojecting, chiral N-C(sp3)-E type pincer complexes

Synthesis of stereoprojecting, chiral N-C(sp3)-E type pincer complexes

A synthetic strategy to generate chiral N-C(sp3)-E (E = S, O) pincer complexes incorporating enhanced stereoprojecting groups at the N-arm site has been established. The synthesis of the tridentate pincer ligand was carried out via palladacycle-catalyzed asymmetric hydrophosphination of N-chelating...

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Main Authors: Balázs, László B., Tay, Wee Shan, Li, Yongxin, Pullarkat, Sumod Appukuttan, Leung, Pak-Hing
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2020
Subjects:
Science::Chemistry
Palladium
Modification
Online Access:https://hdl.handle.net/10356/142536
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1425362020-06-24T02:14:48Z Synthesis of stereoprojecting, chiral N-C(sp3)-E type pincer complexes Balázs, László B. Tay, Wee Shan Li, Yongxin Pullarkat, Sumod Appukuttan Leung, Pak-Hing School of Physical and Mathematical Sciences Science::Chemistry Palladium Modification A synthetic strategy to generate chiral N-C(sp3)-E (E = S, O) pincer complexes incorporating enhanced stereoprojecting groups at the N-arm site has been established. The synthesis of the tridentate pincer ligand was carried out via palladacycle-catalyzed asymmetric hydrophosphination of N-chelating enones. The chelation properties of the substrates were initially demonstrated on C(sp2)-N type palladacycles. The extended substrate scope allows versatile structural modifications on the ligand backbone. Subsequent cyclometalation provided N-C(sp3)-E complexes in a diastereoselective reaction. MOE (Min. of Education, S’pore) 2020-06-24T02:14:48Z 2020-06-24T02:14:48Z 2018 Journal Article Balázs, L. B., Tay, W. S., Li, Y., Pullarkat, S. A., & Leung, P.-H. (2018). Synthesis of stereoprojecting, chiral N-C(sp3)-E type pincer complexes. Organometallics, 37(14), 2272–2285. doi:10.1021/acs.organomet.8b00262 0276-7333 https://hdl.handle.net/10356/142536 10.1021/acs.organomet.8b00262 2-s2.0-85050385521 14 37 2272 2285 en Organometallics © 2018 American Chemical Society. All rights reserved.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic Science::Chemistry
Palladium
Modification
spellingShingle Science::Chemistry
Palladium
Modification
Balázs, László B.
Tay, Wee Shan
Li, Yongxin
Pullarkat, Sumod Appukuttan
Leung, Pak-Hing
Synthesis of stereoprojecting, chiral N-C(sp3)-E type pincer complexes
description A synthetic strategy to generate chiral N-C(sp3)-E (E = S, O) pincer complexes incorporating enhanced stereoprojecting groups at the N-arm site has been established. The synthesis of the tridentate pincer ligand was carried out via palladacycle-catalyzed asymmetric hydrophosphination of N-chelating enones. The chelation properties of the substrates were initially demonstrated on C(sp2)-N type palladacycles. The extended substrate scope allows versatile structural modifications on the ligand backbone. Subsequent cyclometalation provided N-C(sp3)-E complexes in a diastereoselective reaction.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Balázs, László B.
Tay, Wee Shan
Li, Yongxin
Pullarkat, Sumod Appukuttan
Leung, Pak-Hing
format Article
author Balázs, László B.
Tay, Wee Shan
Li, Yongxin
Pullarkat, Sumod Appukuttan
Leung, Pak-Hing
author_sort Balázs, László B.
title Synthesis of stereoprojecting, chiral N-C(sp3)-E type pincer complexes
title_short Synthesis of stereoprojecting, chiral N-C(sp3)-E type pincer complexes
title_full Synthesis of stereoprojecting, chiral N-C(sp3)-E type pincer complexes
title_fullStr Synthesis of stereoprojecting, chiral N-C(sp3)-E type pincer complexes
title_full_unstemmed Synthesis of stereoprojecting, chiral N-C(sp3)-E type pincer complexes
title_sort synthesis of stereoprojecting, chiral n-c(sp3)-e type pincer complexes
publishDate 2020
url https://hdl.handle.net/10356/142536
_version_ 1681057589832450048

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