Enzymatic and structural insights into the mycobacterial alkylhydroperoxide reductase subunit C and repurposing of an antimalaria compound inhibiting the mycobacterial cytochrome BCC oxidase for tuberculosis disease

• Main Author: Chong, Sherilyn Shi Min
• Other Authors: Gerhard Gruber
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2020
• Subjects: Science::Biological sciences; Science::Chemistry::Organic chemistry
• Online Access: https://hdl.handle.net/10356/143914
• Institution: Nanyang Technological University

Tuberculosis (TB) is one of the leading contagious diseases that results in mortality. Treatment with antibiotics has been applied for TB however, with new forms of antibiotic resistance emerging, difficulty in treatment of TB was detected. In this study, alkylhydroperoxide reductase subunit C (MtAh...