Compaction and self-association of megabase-sized chromatin are induced by anionic protein crowding

• Main Authors: Zinchenko, Anatoly, Chen, Qinming, Berezhnoy, Nikolay V., Wang, Sai, Nordenskiöld, Lars
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2020
• Subjects: Science::Biological sciences::Molecular biology; Association Reactions; DNA
• Online Access: https://hdl.handle.net/10356/144055
• Institution: Nanyang Technological University

Highly compacted chromatin, a complex of DNA with cationic histone proteins, is found in the nucleus of eukaryotic cells in an environment with a high concentration of macromolecular species, many of which possess a negative charge. In the majority of previous studies, however, these crowding condit...