Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology
Rapidly dividing cells maintain chromatin supercoiling homeostasis via two specialized classes of enzymes, DNA topoisomerase type 1 and 2 (TOP1/2).Several important anticancer drugs perturb this homeostasis by targetingTOP1/2, thereby generating genotoxic DNA damage. Our recent studies indicated tha...
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| Main Authors: | , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2021
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/146193 |
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| Institution: | Nanyang Technological University |
| Language: | English |