Oncofetal HMGA2 attenuates genotoxic damage induced by topoisomerase II target compounds through the regulation of local DNA topology

• Main Authors: Ahmed, Syed Moiz, Dröge, Peter
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Chemotherapy; DNA Topology
• Online Access: https://hdl.handle.net/10356/146193
• Institution: Nanyang Technological University

Rapidly dividing cells maintain chromatin supercoiling homeostasis via two specialized classes of enzymes, DNA topoisomerase type 1 and 2 (TOP1/2).Several important anticancer drugs perturb this homeostasis by targetingTOP1/2, thereby generating genotoxic DNA damage. Our recent studies indicated tha...