New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis

• Main Authors: Lupien, Andréanne, Foo, Caroline Shi-Yan, Savina, Svetlana, Vocat, Anthony, Piton, Jérémie, Monakhova, Natalia, Benjak, Andrej, Lamprecht, Dirk A., Steyn, Adrie J. C., Pethe, Kevin, Makarov, Vadim A., Cole, Stewart T.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Mycobacterium Tuberculosis; Drug Therapy
• Online Access: https://hdl.handle.net/10356/146858
• Institution: Nanyang Technological University

The emergence of multi-drug (MDR-TB) and extensively-drug resistant tuberculosis (XDR-TB) is a major threat to the global management of tuberculosis (TB) worldwide. New chemical entities are of need to treat drug-resistant TB. In this study, the mode of action of new, potent quinazoline derivatives...