Asymmetric stepwise reductive amination of sulfonamides, sulfamates, and a phosphinamide by nickel catalysis

• Main Authors: Zhao, Xiaohu, Xu, Haiyan, Huang, Xiaolei, Zhou, Steve Jianrong
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Chiral Alkylamines; Nickel Catalysis
• Online Access: https://hdl.handle.net/10356/146874
• Institution: Nanyang Technological University

Asymmetric reductive amination of poorly nucleophilic sulfonamides was realized in the presence of nickel catalysts and titanium alkoxide. A wide range of ketones, including enolizable ketones and some biaryl ones, were converted into sulfonamides in excellent enantiomeric excess. The cyclization of...