Two RNA tunnel inhibitors bind in highly conserved sites in dengue virus NS5 polymerase : structural and functional studies

• Main Authors: Arora, Rishi, Liew, Chong Wai, Soh, Sherryl Tingjin, Otoo, Dorcas Adobea, Seh, Cheah Chen, Yue, Kimberley, Shahul Nilar, Wang, Gang, Yokokawa, Fumiaki, Noble, Christian G., Chen, Yen Liang, Shi, Pei-Yong, Lescar, Julien, Smith, Thomas M., Benson, Timothy E., Lim, Siew Pheng
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Flaviviruses; Dengue Virus
• Online Access: https://hdl.handle.net/10356/147502
• Institution: Nanyang Technological University

Dengue virus (DENV) NS5 RNA-dependent RNA polymerase (RdRp), an important drug target, synthesizes viral RNA and is essential for viral replication. While a number of allosteric inhibitors have been reported for hepatitis C virus RdRp, few have been described for DENV RdRp. Following a diverse compo...