Carbene-catalyzed reaction of indolyl methylenemalononitriles and enals for access to complex tetrahydrocarbazoles

• المؤلفون الرئيسيون: Mou, Chengli, Zhou, Liejin, Song, Runjiang, Chai, Huifang, Hao, Lin, Chi, Robin Yonggui
• مؤلفون آخرون: School of Physical and Mathematical Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2021
• الموضوعات: Science::Chemistry; Chemical Reactions; Reaction Products
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/148641
• المؤسسة: Nanyang Technological University

A carbene-catalyzed enantioselective cascade reaction of substituted methylenemalononitriles and α-bromoenals is disclosed. Key steps of this cascade process include a formal [4 + 2] cycloaddition, aldol reaction, and intramolecular lactonization. Our reaction offers streamlined and highly stereosel...