A novel minimal motif for left-handed G-quadruplex formation

A novel minimal motif for left-handed G-quadruplex formation

A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crysta...

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Bibliographic Details
Main Authors: Das, Poulomi, Winnerdy, Fernaldo Richtia, Maity, Arijit, Mechulam, Yves, Phan, Anh Tuân
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2021
Subjects:
Science::Chemistry::Biochemistry
Science::Biological sciences
G-quadruplexes
Left Handed
Online Access:https://hdl.handle.net/10356/150047
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Institution: Nanyang Technological University
Language: English
Description
Summary:A recent study on the left-handed G-quadruplex (LHG4) DNA revealed a 12-nt minimal motif GTGGTGGTGGTG with the ability to independently form an LHG4 and to drive an adjacent sequence to LHG4 formation. Here we have identified a second LHG4-forming motif, GGTGGTGGTGTG, and determined the X-ray crystal structure of an LHG4 involving this motif. Our structural analysis indicated the role of split guanines and single thymine loops in promoting LHG4 formation.

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