Incorporating G-C pair-recognizing Guanidinium into PNAs for sequence and structure specific recognition of dsRNAs over dsDNAs and ssRNAs

• Main Authors: Krishna, Manchugondanahalli S., Wang, Zhenzhang, Zheng, Liangzhen, Bowry, Jogesh, Ong, Alan Ann Lerk, Mu, Yuguang, Prabakaran, Mookkan, Chen, Gang
• 其他作者: School of Physical and Mathematical Sciences
• 格式: Article
• 語言: English
• 出版: 2021
• 主題: Science::Biological sciences; Guanidinium; Double-stranded RNAs
• 在線閱讀: https://hdl.handle.net/10356/150414

Recognition of RNAs under physiological conditions is important for the development of chemical probes and therapeutic ligands. Nucleobase-modified dsRNA-binding PNAs (dbPNAs) are promising for the recognition of dsRNAs in a sequence and structure specific manner under near-physiological conditions....