Palladium(II)-catalyzed stereospecific alkenyl C-H bond alkylation of allylamines with alkyl iodides

Palladium(II)-catalyzed stereospecific alkenyl C-H bond alkylation of allylamines with alkyl iodides

A palladium-catalyzed stereospecific alkylation of allylamines with primary and secondary alkyl iodides is described. Isoquinoline-1-carboxamide (IQA) acts as directing group to generate multisubstituted olefin products in cis configuration in moderate to good yields. Mechanistic studies suggest tha...

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Bibliographic Details
Main Authors: Luo, Yun-Cheng, Yang, Chao, Qiu, Sheng-Qi, Liang, Qiu-Ju, Xu, Yun-He, Loh, Teck-Peng
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2021
Subjects:
Science::Chemistry
Palladium
Alkylation
Online Access:https://hdl.handle.net/10356/151653
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Institution: Nanyang Technological University
Language: English
Description
Summary:A palladium-catalyzed stereospecific alkylation of allylamines with primary and secondary alkyl iodides is described. Isoquinoline-1-carboxamide (IQA) acts as directing group to generate multisubstituted olefin products in cis configuration in moderate to good yields. Mechanistic studies suggest that alkenyl C-H bond activation is the rate-determining step.

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