Palladium(II)-catalyzed stereospecific alkenyl C-H bond alkylation of allylamines with alkyl iodides

• Main Authors: Luo, Yun-Cheng, Yang, Chao, Qiu, Sheng-Qi, Liang, Qiu-Ju, Xu, Yun-He, Loh, Teck-Peng
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Palladium; Alkylation
• Online Access: https://hdl.handle.net/10356/151653
• Institution: Nanyang Technological University

A palladium-catalyzed stereospecific alkylation of allylamines with primary and secondary alkyl iodides is described. Isoquinoline-1-carboxamide (IQA) acts as directing group to generate multisubstituted olefin products in cis configuration in moderate to good yields. Mechanistic studies suggest tha...