Copper-catalyzed asymmetric arylation of N-heteroaryl aldimines : elementary step of a 1,4-insertion

Copper-catalyzed asymmetric arylation of N-heteroaryl aldimines : elementary step of a 1,4-insertion

Copper complexes of monodentate phosphoramidites efficiently promote asymmetric arylation of N-azaaryl aldimines with arylboroxines. DFT calculations and experiments support an elementary step of 1,4-insertion in the reaction pathway, a step in which an aryl-copper species adds directly across four...

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Bibliographic Details
Main Authors: Wu, Chunlin, Qin, Xurong, Moeljadi, Adhitya Mangala Putra, Hirao, Hajime, Zhou, Steve Jianrong
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2021
Subjects:
Science::Chemistry
Arylation
Asymmetric Catalysis
Online Access:https://hdl.handle.net/10356/151793
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Institution: Nanyang Technological University
Language: English
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Summary:Copper complexes of monodentate phosphoramidites efficiently promote asymmetric arylation of N-azaaryl aldimines with arylboroxines. DFT calculations and experiments support an elementary step of 1,4-insertion in the reaction pathway, a step in which an aryl-copper species adds directly across four atoms of C=N-C=N in the N-azaaryl aldimines.

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