Copper-catalyzed asymmetric arylation of N-heteroaryl aldimines : elementary step of a 1,4-insertion

• Main Authors: Wu, Chunlin, Qin, Xurong, Moeljadi, Adhitya Mangala Putra, Hirao, Hajime, Zhou, Steve Jianrong
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Chemistry; Arylation; Asymmetric Catalysis
• Online Access: https://hdl.handle.net/10356/151793
• Institution: Nanyang Technological University

Copper complexes of monodentate phosphoramidites efficiently promote asymmetric arylation of N-azaaryl aldimines with arylboroxines. DFT calculations and experiments support an elementary step of 1,4-insertion in the reaction pathway, a step in which an aryl-copper species adds directly across four...