Alternative splicing in human myeloid cell differentiation and leukaemia

• المؤلف الرئيسي: Lim, Kai Yi
• مؤلفون آخرون: Francesc Xavier Roca Castella
• التنسيق: Final Year Project
• اللغة: English
• منشور في: Nanyang Technological University 2021
• الموضوعات: Science::Biological sciences::Molecular biology; Science::Biological sciences::Genetics
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/153292
• المؤسسة: Nanyang Technological University

Dysregulation of alternative splicing (AS) has been implicated in aberrant cell function, resulting in diseases such as acute myeloid leukaemia (AML). It was found that myeloid cell differentiation was impaired due to mutations and altered expression levels of splicing factors (SFs). Preliminary dat...