Alternative splicing in human myeloid cell differentiation and leukaemia

• Main Author: Lim, Kai Yi
• Other Authors: Francesc Xavier Roca Castella
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2021
• Subjects: Science::Biological sciences::Molecular biology; Science::Biological sciences::Genetics
• Online Access: https://hdl.handle.net/10356/153292
• Institution: Nanyang Technological University

Dysregulation of alternative splicing (AS) has been implicated in aberrant cell function, resulting in diseases such as acute myeloid leukaemia (AML). It was found that myeloid cell differentiation was impaired due to mutations and altered expression levels of splicing factors (SFs). Preliminary dat...