PD-L1 alternative splicing

PD-L1 is an immune checkpoint molecule which is upregulated in some tumors to evade the immune response. Generation of truncated and nonfunctional PD-L1 variants by modulation of alternative splicing presents a novel strategy for cancer treatments. PD-L1 alternative splicing was studied using minige...

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Bibliographic Details
Main Author: Zhen, Yashu
Other Authors: Francesc Xavier Roca Castella
Format: Thesis-Doctor of Philosophy
Language:English
Published: Nanyang Technological University 2022
Subjects:
Online Access:https://hdl.handle.net/10356/156429
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Institution: Nanyang Technological University
Language: English